Melissa and Ashley

Melissa finds herself overwhelmed with four children, a marriage on the rocks, and an unexpected pregnancy. When Ashley’s weight-loss journey hits a wall, she sets out to get herself back on track towards a healthy lifestyle.

Christina and Paula

Christina’s extreme weight loss has led to unhealthy habits, verging on anorexia. After losing 300 pounds, Paula must endure more surgery to deal with a body entirely covered in loose and sagging excess skin.

Zsalynn and Olivia

Zsalynn wants a fresh start, but her body lift at a Beverly Hills clinic proves challenging. Lonely and depressed since her gastric bypass surgery, Olivia wants skin removal surgery but struggles to lose the weight to qualify.

Bettie Jo and Susan

Bettie Jo battles depression, a cancer diagnosis and an unexpected pregnancy. Susan suffers a major setback after surgery for her excess skin, thwarting her hopes of conquering her obesity.

Joe

Joe celebrates his new life with various, independent adventures but struggles to lose weight and recover after a back injury. Joe has made major strides since being suicidal prior to weight-loss surgery.

Angel and Charity

Angel has lost almost 400 pounds, but her knee pain and history of obesity threaten her progress. Charity must find the strength to return to healthy eating after post-surgery complications.

Laura and Marla

Laura's husband is struggling now that she has lost 300 pounds and is not dependent on him. Marla, one of Dr. Now’s most challenging patients, returns and the fireworks begin all over again.

Chay and Pauline

Pauline must find the will to continue her weight-loss efforts after a medical emergency. Chay finally acknowledges her truth as a transgender woman, but the emotional stress of coming out could threaten her weight-loss journey.

Lupe and Ashley D.

Lupe seems stuck in her weight-loss journey and struggles to qualify for skin surgery. Ashley has lost over 300 pounds, but still has personal difficulties and is struck with sudden paralysis.

Brittani and Sean

Brittani has lost over 300 pounds and tries to qualify for skin surgery to repair the lingering effects of extreme obesity on her body. Sean's weight-loss progress is stalling, and Dr. Now believes Sean's mother may be to blame.

Teretha and Chad

Surgery enables Teretha to finally return to family in Detroit, but it soon threatens to undo her progress. After his gastric bypass, trucker Chad gets back on the road but the job is putting any further weight loss in peril.

Nikki

After losing 250 pounds, Nikki works toward skin surgery that will transform her body. Nikki's progress is derailed when she discovers that a close friend has died from weight-loss surgery, and she is overwhelmed with fears.

Dottie and June

Dottie suffers a tragic loss and tries to stay on track with her weight, while June hopes for skin surgery so she can live the life she has always dreamed of living.

Milla and Charity

Charity has lost 400 pounds but now fears for her daughter, Charly, who is becoming obese. Milla has lost a significant amount of weight and hopes to finally qualify for gastric bypass surgery, despite a personal setback.

Joe W. and Pauline

Once around 800 pounds and housebound, Joe now works to balance his weight-loss goals with wedding planning. Pauline has lost over 300 pounds but still struggles with knee pain and is desperate to qualify for skin surgery.

Laura and Chay

Laura fears complications from skin surgery after her difficult experience following gastric bypass surgery. Chay now lives as a woman and struggles to continue to make progress with her weight loss.

Steven and Justin

Steven's dysfunction escalates, pushing his relationship with Dr. Now to the brink. A risky decision is made to save Steven's life, while his brother Justin makes the move to Houston to finally accept help.

Bettie Jo and Susan

At almost 400 pounds, Bettie Jo's pregnancy is high-risk and strains her marriage. Susan has lost 400 pounds and is enjoying a new relationship but must find a way to stay on track once her weight loss stalls.

Melissa Morris

Melissa lost 500 pounds after gastric bypass surgery. Eleven years and three kids later, she has gained 150 pounds and struggles with life as a single mom. She must choose to focus on her weight loss or risk obesity yet again.

Kandi and Brandi

After successful sleeve gastrectomy procedures, the twins Kandi and Brandi collectively lost more than 400 pounds and are working toward skin surgeries when a major life event disrupts their world and threatens the security they thought they had.

Erica

Erica returns to California to continue her weight-loss journey and fears the loss of structure and support will derail her progress. Erica also struggles to recover from past traumas and fights the urge to binge eat.

Diana and Ashley R.

Ashley R. lost over 200 pounds in Houston but fears returning home to her enabling family in California. Diana has shed 300 pounds and has embraced her renewed lease on life, but knee damage threatens her continued progress.

Kirsten, Michael, and Roni

Kirsten must finally become independent to get the full gastric bypass surgery she feels she needs. Michael struggles to lose weight and still battles anger issues while his wife, Roni, wants her own weight-loss surgery.

James and Cynthia

Back on Dr. Now's program, James is suspected of cheating as he continues to gain weight and suffers a series of life-threatening illnesses. Cynthia continues to lose weight but must push herself to qualify for skin surgery.

Doug

Doug has lost over 200 pounds and is now an active part of his family's life. However, his struggles with an eating disorder and an identity crisis may derail his progress. His wife and therapist help him get back on track.

Nicole and Ashley D.

Ashley is desperate for skin surgery, but her weight loss has stalled and she struggles with depression and insecurity. Nicole is forced to move back to Ohio after being evicted, which could derail her weight-loss journey.

Lupe and Brittani

Brittani has lost over 400 pounds in two years and seeks skin surgery to repair her body. She and her husband consider expanding their family. Lupe has left her husband and works to reclaim her independence, but she struggles to stick to her diet.

Sean and Dottie

Sean must overcome recent tragedies in his life so he can keep building on the progress he's made over the last two years. Dottie struggles to overcome the loss of her son and continue on her weight-loss journey.

Milla and Charity

Milla is still dependent on her children, and she is unsure if she can lose enough weight to walk. Meanwhile, Charity is deeply depressed while her daughter, Charly, battles food addiction, but they must turn things around in order to meet their goals.

The Assanti Brothers

As Steven heals from his weight loss surgery, his brother Justin finally decides to come to Texas to get the same procedure, but Justin's feelings towards Steven immediately begin to sabotage his hopes of surgery.

Janine

A year since her weight loss journey began, Janine is still over 500 lbs and mostly immobile. Now, Dr. Nowzaradan is running out of options for how to treat her if she can't find a way to control her eating habits and start walking again.

Lee and Rena and Sarah

Lee's anger issues continue to jeopardize his relationship with Rena and threaten to derail both of their weight loss journeys, while a major life event sends Sarah into a depression that she must pull herself out of if she wants to keep losing weight.

Sean

In the fourth year of his weight loss journey, Sean struggles to get past the loss of his mother and living on his own. Dr. Now intervenes to control Sean's eating for a time, but if he can't learn to control himself, he will face dire consequences.

Jennifer and Marissa and Liz

Liz has gone from being bedbound with lymphedemas on both legs to standing and walking, but her old fears are about to threaten her progress. Then, if Jenn and Marissa can't get along as mother and daughter to lose weight, they'll have to proceed apart.

Milla

After three years and five surgeries, success for Milla would mean beating the odds and becoming one of Dr. Nowzaradan's most-impressive weight loss patients ever, but failure would mean slipping back to the bedbound life she swore she'd never return to.

June, Chad, and Pauline

Pauline's self-destructive behavior continues to be a problem, and Chad strives to be a better father and husband as he continues his journey. Meanwhile, June's progress stalls when frequent travel and wedding plans cause her to slip back into bad habits.

Tamy and Karina

Tamy faces a tough choice when her husband wants her back but only if she moves away from Houston and Dr. Now's program. Karina's weight loss begins to slow, but she finds happiness dating a guy Dr. Now is surprised to see in his clinic again.

David & Benji & Erica

In year three, Erica is succeeding on her weight loss journey when romantic misfortune sends her spiraling backwards. Benji must reach his goal weight without the support of his brother David after a disagreement leaves the two brothers estranged.

Alicia and Pauline

Alicia's relationship with her boyfriend, Tim, comes under the microscope in the second year of her weight loss journey. Now in her fourth year, Pauline must beg her way back onto the program after quitting in a huff when her last weigh-in didn't go well.

Dottie & Cynthia

Dottie faces an unexpected challenge to her weight loss when her husband's drinking problem becomes intolerable for her and her son. Cynthia starts to wonder if being there for her kids at her current weight is more important than losing more.

Charity & Charly & Teretha

In order to keep pace with her daughter Charly's impressive weight loss, Charity must do something she's never done: find a way to go it alone. Try as she might, Teretha finds one too many obstacles in the way of continuing with Dr. Nowzaradan's program.

One-Ton Family

Together weighing more than a ton, siblings Roshanda, Brandie and Clarence set out to lose weight as a family. But the all-for-one approach may be hurting more than it helps when each of them shows signs of heading in the wrong direction after surgery.

The Assanti Brothers

If Steve Sr. thought getting weight-loss surgery for both of his sons would help bring them together, the third year of their weight-loss journey will prove him wrong. Justin returns to Rhode Island with every intention of never speaking to Steven again.

Maja and Justin

Maja needs weight-loss surgery so she can lose weight, but Dr. Now won't approve her for surgery if she can't overcome getting dumped by her boyfriend Christian without using food to cope. Justin charts a course to be one of Dr. Now's best patients ever.

Brianne and Annjeanette

There is much to be gained -- and lost -- for Brianne in year two of her journey, in which she both loses weight and gains independence. Getting back with Erica becomes the top priority for Annjeanette, who chooses love over even her own health.

Angie J: Part 1

Right when Angie starts to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos. Angie moves ahead despite dire difficulties, but when her body starts to break down, Angie fears the worst ... and faces it alone.

Angie J: Part 2

Angie enters the most-trying stretch of her weight-loss journey. She finds herself on the brink of homelessness after Dr. Now refuses to keep her in his program unless she submits to drug rehab for substance abuse.

Jeanne and Brandon

Jeanne struggles to care for herself in the aftermath of her dad's death. Brandon strives to get his weight down in order to feel confident when proposing to his girlfriend Tayler and be the man she deserves.

Cillas and Tiffany

Cillas must face difficulties from his childhood in order to progress to his goal weight and set an example for his children. Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend Aaron.

John and Lonnie

After a year of forced isolation due to COVID-19, brothers John and Lonnie return to see Dr. Now with a staggering collective weight loss that puts them in rare company as some of his most successful patients ever.

Holly and Lashanta

Holly has come a long way in her weight loss journey, but now she's trying to balance a wedding and skin surgery. Lashanta struggles to lose any weight at all. When a car drives through a wall in her living room, her weight loss is curtailed even more.

Robin and Garrett

Robin and Garrett started their weight-loss journeys together as aunt and nephew. Now almost four years later, they're like war buddies, striving to reach their target weights through a combination of shedding pounds and skin removal surgeries.

Vianey and Allen

Vianey and Allen have been on a weight loss journey together. But after Allen's surgery is a success and Vianey's is not, the couple struggles to get back on the same page to save their lives.

Octavia and Aaron

After regaining her mobility, Octavia is determined never to be stuck in the bed again, but difficult life circumstances threaten her ability to eat right and stay on track. Aaron is laid low by the death of his father, but true love saves him.

Lacey and Mercedes

Even after surgery, Lacey's weight loss moves at a glacial pace. She says she wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight. Meanwhile, abandoned in Houston by her cousin, Mercedes and her kids face destitution.